{"id":1729,"date":"2025-11-03T12:05:44","date_gmt":"2025-11-03T12:05:44","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1729"},"modified":"2025-11-03T12:05:44","modified_gmt":"2025-11-03T12:05:44","slug":"meroterpenoids-source-bioaactivity-review","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/11\/03\/meroterpenoids-source-bioaactivity-review\/","title":{"rendered":"Benzo-fused ten-membered ring meroterpenoids: sources, chemical diversity, biological activities, and biosynthesis"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em><\/a> journal. Meroterpenoids, a class of hybrid natural products derived from both terpenoid and non-terpenoid biosynthetic pathways, serve as a prolific source of drug leads, because of their structural complexity and extensive bioactivities.<\/p>\n

Meroterpenoids have provided many clinical drugs or promising leads, such as mycophenolic acid (an immunosuppressant), territrem B (an acetylcholinesterase inhibitor), and pyripyropene A (a cholesterol acyltransferase-2 inhibitor). Recently, meroterpenoids featuring a benzo-fused ten-membered ring skeleton have attracted considerable attention for their unique scaffolds and diverse post-modifications. Bioactivity evaluations have revealed that nearly half of these compounds (32 of 66) exhibit cytotoxicity with half-maximal inhibitory concentrations below 10 \u03bcM, and therefore have great potential as drug development candidates, particularly in cancer therapy. However, a systematic summary of this subclass remains lacking.<\/p>\n

This article summarizes benzo-fused ten-membered ring meroterpenoids reported between 1980 and 2024, including their sources, structural diversity, bioactivities, and biosynthetic pathways, to provide comprehensive insights to guide further studies on meroterpenoids.<\/p>\n

Read More:\u00a0https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0029<\/a><\/p>\n

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Wenjie Luo, Ruishan Wang and Dani\u00e8le Werck-Reichhart et al. Benzo-fused ten-membered ring meroterpenoids: sources, chemical diversity, biological activities, and biosynthesis.\u00a0Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(4):630-656. DOI: 10.15212\/AMM-2025-0029<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Meroterpenoids, a class of hybrid natural products derived from both terpenoid and non-terpenoid biosynthetic pathways, serve as a prolific source of drug leads, because of their structural complexity and extensive bioactivities. Meroterpenoids have provided many clinical drugs or promising leads, such as mycophenolic acid (an immunosuppressant), […]<\/p>\n","protected":false},"author":5,"featured_media":1730,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[525,532,79,530,531,358],"class_list":["post-1729","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-bioactivity","tag-biosynthesis","tag-cancer-therapy","tag-meroterpenoids","tag-phytochemicals","tag-terpenoids"],"yoast_head":"\nBenzo-fused ten-membered ring meroterpenoids: sources, chemical diversity, biological activities, and biosynthesis<\/title>\n<meta name=\"description\" content=\"Reviewing the sources, structural diversity, bioactivities, and biosynthetic pathways of benzo-fused ten-membered ring meroterpenoids.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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