{"id":1650,"date":"2025-07-10T09:57:16","date_gmt":"2025-07-10T09:57:16","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1650"},"modified":"2025-07-10T09:57:16","modified_gmt":"2025-07-10T09:57:16","slug":"biomaterials-drugdelivery-diabetesmellitus","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/","title":{"rendered":"Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. Bioresponsive materials have gained prominence as innovative tools for advancing drug delivery systems, particularly in managing type 1 and type 2 diabetes mellitus. These materials respond to biological stimuli such as pH, glucose, enzymes, or temperature, thereby enabling spatiotemporally controlled drug release. This article examines recent progress in the design strategies, activation mechanisms, and therapeutic applications of these materials in diabetes care. Key focus areas include macromolecular insulin delivery systems and oral hypoglycemic agents, with emphasis on their efficacy in regulating blood glucose homeostasis. Despite their promise, challenges persist in translating these technologies to clinical practice, including scalability limitations, insufficient clinical validation, regulatory hurdles, and healthcare system compatibility. Current therapeutic shortcomings, such as frequent injections and adverse effects compromising patient adherence, are discussed. By synthesizing contemporary research developments and implementation barriers, this work provides critical insights into optimizing bioresponsive platforms for clinical translation. The analysis underscores the need for interdisciplinary approaches to address technical and practical constraints, and ultimately engineer patient-centric, scalable solutions that enhance therapeutic outcomes and quality of life. Future directions include bridging material innovation with clinical needs to develop next-generation diabetes management systems.<\/p>\n

Read full article: https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0020<\/a><\/p>\n

# # # # # #<\/strong><\/p>\n

Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n

Submission Process<\/strong><\/p>\n

Submissions to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n

Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n

Please visit https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n

Editorial Board:<\/strong> https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n

There are no author submission or article processing fees.<\/p>\n

Follow Acta Materia Medica <\/em><\/strong>on Twitter https:\/\/twitter.com\/AMM_journal<\/a>; Facebook<\/a> (https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n

eISSN <\/strong>2737-7946<\/p>\n

# # # # # #<\/strong><\/p>\n

Mageta Samwel Mageta, Yusuf Nasir Maigari and Yingqi Tang et al. Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus.\u00a0Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(4):549-569. DOI: 10.15212\/AMM-2025-0020<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Bioresponsive materials have gained prominence as innovative tools for advancing drug delivery systems, particularly in managing type 1 and type 2 diabetes mellitus. These materials respond to biological stimuli such as pH, glucose, enzymes, or temperature, thereby enabling spatiotemporally controlled drug release. This article examines recent […]<\/p>\n","protected":false},"author":5,"featured_media":1651,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[521,520,524,522,514,523,38],"class_list":["post-1650","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-biomaterials","tag-bioresponsive","tag-bioresponsive-materials","tag-diabetes-mellitus","tag-drug-delivery","tag-glucose-sensitive-materials","tag-nanoparticles"],"yoast_head":"\nInnovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus<\/title>\n<meta name=\"description\" content=\"Reviewing the latest progress and challenges in bioresponsive materials and their application for effective drug delivery in diabetes mellitus.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus\" \/>\n<meta property=\"og:description\" content=\"Reviewing the latest progress and challenges in bioresponsive materials and their application for effective drug delivery in diabetes mellitus.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/\" \/>\n<meta property=\"og:site_name\" content=\"AMM Journal\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-10T09:57:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/Innovations-and-challenges-in-bioresponsive-materials.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"628\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Suresh PDMR\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Suresh PDMR\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/\"},\"author\":{\"name\":\"Suresh PDMR\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\"},\"headline\":\"Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus\",\"datePublished\":\"2025-07-10T09:57:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/\"},\"wordCount\":360,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Innovations-and-challenges-in-bioresponsive-materials.jpg\",\"keywords\":[\"biomaterials\",\"bioresponsive\",\"Bioresponsive materials\",\"diabetes mellitus\",\"drug delivery\",\"glucose-sensitive materials\",\"nanoparticles\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/\",\"name\":\"Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Innovations-and-challenges-in-bioresponsive-materials.jpg\",\"datePublished\":\"2025-07-10T09:57:16+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\"},\"description\":\"Reviewing the latest progress and challenges in bioresponsive materials and their application for effective drug delivery in diabetes mellitus.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/#primaryimage\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Innovations-and-challenges-in-bioresponsive-materials.jpg\",\"contentUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Innovations-and-challenges-in-bioresponsive-materials.jpg\",\"width\":1200,\"height\":628,\"caption\":\"Bioresponsive materials\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/10\\\/biomaterials-drugdelivery-diabetesmellitus\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/amm-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/\",\"name\":\"AMM Journal\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/amm-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\",\"name\":\"Suresh PDMR\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"caption\":\"Suresh PDMR\"},\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/author\\\/suresh\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus","description":"Reviewing the latest progress and challenges in bioresponsive materials and their application for effective drug delivery in diabetes mellitus.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/","og_locale":"en_GB","og_type":"article","og_title":"Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus","og_description":"Reviewing the latest progress and challenges in bioresponsive materials and their application for effective drug delivery in diabetes mellitus.","og_url":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/","og_site_name":"AMM Journal","article_published_time":"2025-07-10T09:57:16+00:00","og_image":[{"width":1200,"height":628,"url":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/Innovations-and-challenges-in-bioresponsive-materials.jpg","type":"image\/jpeg"}],"author":"Suresh PDMR","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Suresh PDMR","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/#article","isPartOf":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/"},"author":{"name":"Suresh PDMR","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e"},"headline":"Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus","datePublished":"2025-07-10T09:57:16+00:00","mainEntityOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/"},"wordCount":360,"commentCount":0,"image":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/#primaryimage"},"thumbnailUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/Innovations-and-challenges-in-bioresponsive-materials.jpg","keywords":["biomaterials","bioresponsive","Bioresponsive materials","diabetes mellitus","drug delivery","glucose-sensitive materials","nanoparticles"],"articleSection":["News and Events"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/","url":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/","name":"Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus","isPartOf":{"@id":"https:\/\/amm-journal.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/#primaryimage"},"image":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/#primaryimage"},"thumbnailUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/Innovations-and-challenges-in-bioresponsive-materials.jpg","datePublished":"2025-07-10T09:57:16+00:00","author":{"@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e"},"description":"Reviewing the latest progress and challenges in bioresponsive materials and their application for effective drug delivery in diabetes mellitus.","breadcrumb":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/#primaryimage","url":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/Innovations-and-challenges-in-bioresponsive-materials.jpg","contentUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/Innovations-and-challenges-in-bioresponsive-materials.jpg","width":1200,"height":628,"caption":"Bioresponsive materials"},{"@type":"BreadcrumbList","@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/10\/biomaterials-drugdelivery-diabetesmellitus\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/amm-journal.org\/"},{"@type":"ListItem","position":2,"name":"Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus"}]},{"@type":"WebSite","@id":"https:\/\/amm-journal.org\/#website","url":"https:\/\/amm-journal.org\/","name":"AMM Journal","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/amm-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e","name":"Suresh PDMR","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","caption":"Suresh PDMR"},"url":"https:\/\/amm-journal.org\/index.php\/author\/suresh\/"}]}},"_links":{"self":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1650","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=1650"}],"version-history":[{"count":1,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1650\/revisions"}],"predecessor-version":[{"id":1652,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1650\/revisions\/1652"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media\/1651"}],"wp:attachment":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=1650"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=1650"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=1650"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}