{"id":1632,"date":"2025-07-01T07:33:13","date_gmt":"2025-07-01T07:33:13","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1632"},"modified":"2025-07-01T09:18:33","modified_gmt":"2025-07-01T09:18:33","slug":"transdermal-delivery-insulin-microneedles","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/","title":{"rendered":"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems"},"content":{"rendered":"

\"FormulationAnnouncing a new publication for Acta Materia Medica<\/em> journal. \u00a0The prevalence of diabetes is increasing and expected to become a major global health burden. Various pharmaceutical approaches have been used to manage diabetes and reduce the associated risks. Subcutaneous insulin injection remains the primary treatment due to the physicochemical properties of insulin, which limit oral absorption. The gastrointestinal tract presents further challenges, including enzymatic degradation and harsh environmental conditions, resulting in oral insulin bioavailability < 1%. As a result, alternative delivery routes, such as transdermal delivery, have been extensively explored. However, this approach is also challenging due to the structural barriers of the skin, which hinder drug absorption. The high molecular weight of insulin further limits permeation across the skin.<\/p>\n

Read more: https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0019<\/a><\/p>\n

<\/p>\n

To address these limitations, various formulation and delivery strategies have been investigated to improve transdermal drug delivery of insulin and are the subject of this review. Approaches, including penetration enhancers, lipid-based carriers, microemulsion, polymeric systems, and physical enhancement technologies, have demonstrated potential for enhancing skin permeability. However, the potential adverse effects and patient discomfort associated with these conventional methods highlights the need for more user-friendly alternatives. Microneedles have emerged as a promising transdermal delivery system, offering a painless, simple, and user-friendly approach to overcome challenges, thus improving adherence and treatment efficacy.<\/p>\n

# # # # # #<\/strong><\/p>\n

Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n

Submission Process<\/strong><\/p>\n

Submissions to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n

Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n

Please visit https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n

Editorial Board:<\/strong> https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n

There are no author submission or article processing fees.<\/p>\n

 <\/p>\n

Follow Acta Materia Medica <\/em><\/strong>on Twitter https:\/\/twitter.com\/AMM_journal<\/a>; Facebook<\/a> (https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n

eISSN <\/strong>2737-7946<\/p>\n

# # # # # #<\/strong><\/p>\n

Eileen Hulambukie, Mengyang Liu and Wei Wu et al. Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems.\u00a0Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(3):466-492. DOI: 10.15212\/AMM-2025-0019<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. \u00a0The prevalence of diabetes is increasing and expected to become a major global health burden. Various pharmaceutical approaches have been used to manage diabetes and reduce the associated risks. Subcutaneous insulin injection remains the primary treatment due to the physicochemical properties of insulin, which limit oral […]<\/p>\n","protected":false},"author":5,"featured_media":1633,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[502,503,37,506,507,34,504,501,505],"class_list":["post-1632","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-diabetes-mellitus-formulations","tag-insulin","tag-liposomes","tag-microemulsions","tag-microneedles","tag-niosomes","tag-skin-penetration-enhancers","tag-transdermal-delivery-systems","tag-transferosomes"],"yoast_head":"\nFormulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems<\/title>\n<meta name=\"description\" content=\"Strategies for improved transdermal drug delivery of Insulin\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems\" \/>\n<meta property=\"og:description\" content=\"Strategies for improved transdermal drug delivery of Insulin\" \/>\n<meta property=\"og:url\" content=\"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/\" \/>\n<meta property=\"og:site_name\" content=\"AMM Journal\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-01T07:33:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-01T09:18:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/amm20250019_fig2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2008\" \/>\n\t<meta property=\"og:image:height\" content=\"747\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Suresh PDMR\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Suresh PDMR\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/\"},\"author\":{\"name\":\"Suresh PDMR\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\"},\"headline\":\"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems\",\"datePublished\":\"2025-07-01T07:33:13+00:00\",\"dateModified\":\"2025-07-01T09:18:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/\"},\"wordCount\":377,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/amm20250019_fig2.jpg\",\"keywords\":[\"Diabetes mellitus formulations\",\"Insulin\",\"liposomes\",\"Microemulsions\",\"Microneedles\",\"niosomes\",\"Skin penetration enhancers\",\"Transdermal delivery systems\",\"Transferosomes\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/\",\"name\":\"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/amm20250019_fig2.jpg\",\"datePublished\":\"2025-07-01T07:33:13+00:00\",\"dateModified\":\"2025-07-01T09:18:33+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\"},\"description\":\"Strategies for improved transdermal drug delivery of Insulin\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/#primaryimage\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/amm20250019_fig2.jpg\",\"contentUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/amm20250019_fig2.jpg\",\"width\":2008,\"height\":747,\"caption\":\"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/07\\\/01\\\/transdermal-delivery-insulin-microneedles\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/amm-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/\",\"name\":\"AMM Journal\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/amm-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\",\"name\":\"Suresh PDMR\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"caption\":\"Suresh PDMR\"},\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/author\\\/suresh\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems","description":"Strategies for improved transdermal drug delivery of Insulin","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/","og_locale":"en_GB","og_type":"article","og_title":"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems","og_description":"Strategies for improved transdermal drug delivery of Insulin","og_url":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/","og_site_name":"AMM Journal","article_published_time":"2025-07-01T07:33:13+00:00","article_modified_time":"2025-07-01T09:18:33+00:00","og_image":[{"width":2008,"height":747,"url":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/amm20250019_fig2.jpg","type":"image\/jpeg"}],"author":"Suresh PDMR","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Suresh PDMR","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/#article","isPartOf":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/"},"author":{"name":"Suresh PDMR","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e"},"headline":"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems","datePublished":"2025-07-01T07:33:13+00:00","dateModified":"2025-07-01T09:18:33+00:00","mainEntityOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/"},"wordCount":377,"commentCount":0,"image":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/#primaryimage"},"thumbnailUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/amm20250019_fig2.jpg","keywords":["Diabetes mellitus formulations","Insulin","liposomes","Microemulsions","Microneedles","niosomes","Skin penetration enhancers","Transdermal delivery systems","Transferosomes"],"articleSection":["News and Events"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/","url":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/","name":"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems","isPartOf":{"@id":"https:\/\/amm-journal.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/#primaryimage"},"image":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/#primaryimage"},"thumbnailUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/amm20250019_fig2.jpg","datePublished":"2025-07-01T07:33:13+00:00","dateModified":"2025-07-01T09:18:33+00:00","author":{"@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e"},"description":"Strategies for improved transdermal drug delivery of Insulin","breadcrumb":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/#primaryimage","url":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/amm20250019_fig2.jpg","contentUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/07\/amm20250019_fig2.jpg","width":2008,"height":747,"caption":"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems"},{"@type":"BreadcrumbList","@id":"https:\/\/amm-journal.org\/index.php\/2025\/07\/01\/transdermal-delivery-insulin-microneedles\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/amm-journal.org\/"},{"@type":"ListItem","position":2,"name":"Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems"}]},{"@type":"WebSite","@id":"https:\/\/amm-journal.org\/#website","url":"https:\/\/amm-journal.org\/","name":"AMM Journal","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/amm-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e","name":"Suresh PDMR","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","caption":"Suresh PDMR"},"url":"https:\/\/amm-journal.org\/index.php\/author\/suresh\/"}]}},"_links":{"self":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1632","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=1632"}],"version-history":[{"count":1,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1632\/revisions"}],"predecessor-version":[{"id":1634,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1632\/revisions\/1634"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media\/1633"}],"wp:attachment":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=1632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=1632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=1632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}