{"id":1515,"date":"2025-06-16T09:19:31","date_gmt":"2025-06-16T09:19:31","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1515"},"modified":"2025-06-16T09:32:17","modified_gmt":"2025-06-16T09:32:17","slug":"therapeutic-strategies-targeting-srebp","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/06\/16\/therapeutic-strategies-targeting-srebp\/","title":{"rendered":"Therapeutic strategies targeting SREBP transcription factors"},"content":{"rendered":"<p>Announcing a new publication for <em>Acta Materia Medica<\/em> journal. In addition to regulating lipid biosynthesis and uptake, sterol regulatory element binding protein (SREBP) is involved in mediating biological signaling networks.<\/p>\n<p>SREBP is a key transcription factor in the regulation of physiologic and pathologic lipid metabolism processes. \u201cSREBP\u201d was used as a keyword in searches on the Web of Science, Elsevier, Science Direct, and CNKI databases for relevant literature from 2021 to October 2024; the search results were analyzed. SREBP is first synthesized as an inactive precursor, then cleaved to release active NH2-terminal domains. Mature SREBP enters the nucleus and promotes transcription of downstream genes by binding to the promoter elements of target genes. The classical pathway of SREBP precursor activation refers to transporter cleavage that is dependent on SCAP in response to signals from intracellular sterol depletion. However, in the case of endoplasmic reticulum stress, SREBP is activated via caspase-2 and independent of feedback inhibition by steroids or excess lipid uptake.<\/p>\n<p>The mechanism of action underlying SREBP in different diseases, as well as synthetic and natural compounds that inhibit SREBP activity, are also summarized providing new insights into SREBP as a therapeutic target for diseases.<\/p>\n<p>Read full open access article at <a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0001\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0001<\/a><\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p><em>Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n<p><strong>Submission Process<\/strong><\/p>\n<p>Submissions <em>to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at <a href=\"https:\/\/mc04.manuscriptcentral.com\/ammed\">https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n<p>Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n<p>Please visit <a href=\"https:\/\/amm-journal.org\/\">https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/amm-journal.org\/index.php\/editorial-board\/\">https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Acta Materia Medica <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/AMM_journal\">https:\/\/twitter.com\/AMM_journal<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/AMMjournal\">https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7946<\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p>Yongdan Wang, Haitao Xiao and Lina Lai et al. Therapeutic strategies targeting SREBP transcription factors: an update to 2024.\u00a0<em>Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(3):437-465. DOI: 10.15212\/AMM-2025-0001<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new publication for Acta Materia Medica journal. In addition to regulating lipid biosynthesis and uptake, sterol regulatory element binding protein (SREBP) is involved in mediating biological signaling networks. SREBP is a key transcription factor in the regulation of physiologic and pathologic lipid metabolism processes. \u201cSREBP\u201d was used as a keyword in searches on [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":1516,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[497,496,499,500],"class_list":["post-1515","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-metabolism-regulation","tag-srebps","tag-therapeutic-strategies","tag-transcription-factors"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Therapeutic strategies targeting SREBP transcription factors<\/title>\n<meta name=\"description\" content=\"Mechanism of action underlying SREBP in different diseases and its targeted inhibition for disease prevention and 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