{"id":1499,"date":"2025-05-21T07:35:47","date_gmt":"2025-05-21T07:35:47","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1499"},"modified":"2025-05-21T07:37:17","modified_gmt":"2025-05-21T07:37:17","slug":"protacs-improve-selectivity-for-targeted-proteins","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/05\/21\/protacs-improve-selectivity-for-targeted-proteins\/","title":{"rendered":"PROTACs improve selectivity for targeted proteins"},"content":{"rendered":"<p><img decoding=\"async\" class=\"wp-image-1501 size-thumbnail alignright\" src=\"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/large-10-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" srcset=\"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/large-10-150x150.jpg 150w, https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/large-10.jpg 223w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>Announcing a new publication for <em>Acta Materia Medica<\/em> journal. \u00a0Proteolysis targeting chimera (PROTAC) technology has emerged as a powerful tool in drug discovery that enables targeted protein degradation through a unique bifunctional approach. This review provides a comprehensive overview of PROTACs with a focus on recent advances in enhancing selectivity and therapeutic potential. We begin with an in-depth discussion of the structure and mechanism of PROTACs, comparing PROTACs to traditional small molecule inhibitors and exploring how PROTACs overcome limitations, such as drug resistance and targeting previously undruggable proteins. Key to this discussion is the concept of selectivity in PROTAC design, including optimization of E3 ligases and linker structures to improve target engagement and minimize off-target effects. The review also highlights the potential of covalent PROTACs in enhancing specificity and efficacy. Furthermore, various target classes for PROTAC development are explored,<!--more--> including epigenetic regulators (e.g., BET proteins and histone deacetylases), cell cycle and signaling pathway proteins (e.g., CDKs, BCL-XL, and p38 MAPK), receptor and kinase targets (e.g., EGFR and BRAF), and immune regulators (e.g., CREBBP and IRAK3). The implications of targeting these proteins for cancer and other diseases is discussed, emphasizing the promise of PROTACs in transforming therapeutic strategies. Finally, the review highlights ongoing challenges, such as optimizing pharmacokinetics and clinical validation, and provides future perspectives on the evolution of PROTAC technology.<\/p>\n<p>Read full open access article at ScienceOpen: <a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0015\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0015<\/a><\/p>\n<p><em>Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n<p><strong>Submission Process<\/strong><\/p>\n<p>Submissions <em>to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at <a href=\"https:\/\/mc04.manuscriptcentral.com\/ammed\">https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n<p>Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n<p>Please visit <a href=\"https:\/\/amm-journal.org\/\">https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/amm-journal.org\/index.php\/editorial-board\/\">https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>&nbsp;<\/p>\n<p>Follow <strong><em>Acta Materia Medica <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/AMM_journal\">https:\/\/twitter.com\/AMM_journal<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/AMMjournal\">https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7946<\/p>\n<p>&nbsp;<\/p>\n<p>Lihua Liu, Xian Guan and Jiezhen Zhuo et al. PROTACs improve selectivity for targeted proteins.\u00a0<em>Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(3):390-412. DOI: 10.15212\/AMM-2025-0015<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new publication for Acta Materia Medica journal. \u00a0Proteolysis targeting chimera (PROTAC) technology has emerged as a powerful tool in drug discovery that enables targeted protein degradation through a unique bifunctional approach. This review provides a comprehensive overview of PROTACs with a focus on recent advances in enhancing selectivity and therapeutic potential. We begin [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":1501,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[63,489,486,487,488],"class_list":["post-1499","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-degradation","tag-pan-inhibitors","tag-protacs","tag-targeting-selectivity","tag-ubiquitination"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PROTACs improve selectivity for targeted proteins<\/title>\n<meta name=\"description\" content=\"PROTACs offer a novel approach to degrade disease-causing proteins, showing promise in targeting cancers and drug-resistant proteins with high selectivity.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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