{"id":1495,"date":"2025-05-16T07:09:37","date_gmt":"2025-05-16T07:09:37","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1495"},"modified":"2025-05-16T07:09:37","modified_gmt":"2025-05-16T07:09:37","slug":"ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/","title":{"rendered":"Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. Tumor ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, has emerged as a promising therapeutic strategy for combating cancers, particularly in cases involving cancer stem cells (CSCs) and drug resistance. In recent years nanomaterial-based approaches have gained significant attention for the potential to selectively induce ferroptosis in cancer cells while sparing normal tissues. This review article aims to provide a comprehensive overview of the current state-of-the-art in utilizing nanomaterials for targeting tumor ferroptosis with a specific focus on the application in eradicating CSCs and overcoming drug resistance mechanisms. The molecular mechanisms underlying ferroptosis induction by nanomaterials, the unique properties and functionalities of various nanomaterial platforms, and strategies for targeting CSCs and overcoming drug resistance using nanoferroptosis approaches are discussed. In addition, the preclinical and clinical evidence supporting the efficacy of nanomaterial platforms are evaluated. Furthermore, the challenges and future perspectives in the development and translation of nanoferroptosis-based therapies for precision cancer treatment are highlighted.<\/p>\n

Read full open access article at ScienceOpen: https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2024-0083<\/a><\/p>\n

# # # # # #<\/strong><\/p>\n

Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n

Submission Process<\/strong><\/p>\n

Submissions to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n

Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n

Please visit https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n

Editorial Board:<\/strong> https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n

There are no author submission or article processing fees.<\/p>\n

Follow Acta Materia Medica <\/em><\/strong>on Twitter https:\/\/twitter.com\/AMM_journal<\/a>; Facebook<\/a> (https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n

eISSN <\/strong>2737-7946<\/p>\n

# # # # # #<\/strong><\/p>\n

Xiaoman Wang, Jing Luo and Xuemei Zeng et al. Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance.\u00a0Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(3):358-389. DOI: 10.15212\/AMM-2024-0083<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Tumor ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, has emerged as a promising therapeutic strategy for combating cancers, particularly in cases involving cancer stem cells (CSCs) and drug resistance. In recent years nanomaterial-based approaches have gained significant attention for the potential […]<\/p>\n","protected":false},"author":5,"featured_media":1496,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[483,482,115,485,484],"class_list":["post-1495","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-cancer-stem-cell","tag-drug-resistance","tag-ferroptosis","tag-ferroptosis-focused-nanomaterials","tag-nanomaterials"],"yoast_head":"\nFerroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance<\/title>\n<meta name=\"description\" content=\"Ferroptosis-focused nanomaterials eradicate cancer stem cells and overcome drug resistance via iron-driven lipid peroxidation in precision oncology\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance\" \/>\n<meta property=\"og:description\" content=\"Ferroptosis-focused nanomaterials eradicate cancer stem cells and overcome drug resistance via iron-driven lipid peroxidation in precision oncology\" \/>\n<meta property=\"og:url\" content=\"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/\" \/>\n<meta property=\"og:site_name\" content=\"AMM Journal\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-16T07:09:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Ferroptosis-by-nanomaterials.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1535\" \/>\n\t<meta property=\"og:image:height\" content=\"1548\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Suresh PDMR\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Suresh PDMR\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/\"},\"author\":{\"name\":\"Suresh PDMR\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\"},\"headline\":\"Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance\",\"datePublished\":\"2025-05-16T07:09:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/\"},\"wordCount\":332,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Ferroptosis-by-nanomaterials.jpg\",\"keywords\":[\"cancer stem cell\",\"drug resistance\",\"ferroptosis\",\"Ferroptosis-focused nanomaterials\",\"nanomaterials\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/\",\"name\":\"Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Ferroptosis-by-nanomaterials.jpg\",\"datePublished\":\"2025-05-16T07:09:37+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\"},\"description\":\"Ferroptosis-focused nanomaterials eradicate cancer stem cells and overcome drug resistance via iron-driven lipid peroxidation in precision oncology\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/#primaryimage\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Ferroptosis-by-nanomaterials.jpg\",\"contentUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Ferroptosis-by-nanomaterials.jpg\",\"width\":1535,\"height\":1548,\"caption\":\"Ferroptosis by nanomaterials\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/16\\\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/amm-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/\",\"name\":\"AMM Journal\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/amm-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\",\"name\":\"Suresh PDMR\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"caption\":\"Suresh PDMR\"},\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/author\\\/suresh\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance","description":"Ferroptosis-focused nanomaterials eradicate cancer stem cells and overcome drug resistance via iron-driven lipid peroxidation in precision oncology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/","og_locale":"en_GB","og_type":"article","og_title":"Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance","og_description":"Ferroptosis-focused nanomaterials eradicate cancer stem cells and overcome drug resistance via iron-driven lipid peroxidation in precision oncology","og_url":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/","og_site_name":"AMM Journal","article_published_time":"2025-05-16T07:09:37+00:00","og_image":[{"width":1535,"height":1548,"url":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Ferroptosis-by-nanomaterials.jpg","type":"image\/jpeg"}],"author":"Suresh PDMR","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Suresh PDMR","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/#article","isPartOf":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/"},"author":{"name":"Suresh PDMR","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e"},"headline":"Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance","datePublished":"2025-05-16T07:09:37+00:00","mainEntityOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/"},"wordCount":332,"commentCount":0,"image":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/#primaryimage"},"thumbnailUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Ferroptosis-by-nanomaterials.jpg","keywords":["cancer stem cell","drug resistance","ferroptosis","Ferroptosis-focused nanomaterials","nanomaterials"],"articleSection":["News and Events"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/","url":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/","name":"Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance","isPartOf":{"@id":"https:\/\/amm-journal.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/#primaryimage"},"image":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/#primaryimage"},"thumbnailUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Ferroptosis-by-nanomaterials.jpg","datePublished":"2025-05-16T07:09:37+00:00","author":{"@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e"},"description":"Ferroptosis-focused nanomaterials eradicate cancer stem cells and overcome drug resistance via iron-driven lipid peroxidation in precision oncology","breadcrumb":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/#primaryimage","url":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Ferroptosis-by-nanomaterials.jpg","contentUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Ferroptosis-by-nanomaterials.jpg","width":1535,"height":1548,"caption":"Ferroptosis by nanomaterials"},{"@type":"BreadcrumbList","@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/16\/ferroptosis-nanomaterials-cancer-stem-cells-drug-resistance\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/amm-journal.org\/"},{"@type":"ListItem","position":2,"name":"Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance"}]},{"@type":"WebSite","@id":"https:\/\/amm-journal.org\/#website","url":"https:\/\/amm-journal.org\/","name":"AMM Journal","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/amm-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e","name":"Suresh PDMR","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","caption":"Suresh PDMR"},"url":"https:\/\/amm-journal.org\/index.php\/author\/suresh\/"}]}},"_links":{"self":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1495","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=1495"}],"version-history":[{"count":1,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1495\/revisions"}],"predecessor-version":[{"id":1497,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1495\/revisions\/1497"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media\/1496"}],"wp:attachment":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=1495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=1495"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=1495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}