{"id":1492,"date":"2025-05-15T12:17:47","date_gmt":"2025-05-15T12:17:47","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1492"},"modified":"2025-05-15T12:17:47","modified_gmt":"2025-05-15T12:17:47","slug":"hiv-treatment-capsid-inhibitor-lenacapavir","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/hiv-treatment-capsid-inhibitor-lenacapavir\/","title":{"rendered":"Revolutionizing HIV treatment: unveiling the new frontiers of HIV capsid research"},"content":{"rendered":"<p>Announcing a new publication for <em>Acta Materia Medica<\/em> journal. The HIV-1 capsid protein (CA) plays a crucial role in viral replication by orchestrating nuclear entry through interactions with host nuclear pore complexes (NPCs). Recent research has revealed that HIV-1 CA actively disrupts NPC architecture via phenylalanine-glycine (FG)-repeat nucleoporin interactions, thereby enabling nuclear translocation of viral components. This mechanistic insight has driven the development of lenacapavir, the first-in-class CA inhibitor approved for multidrug-resistant HIV-1. Lenacapavir competitively blocks CA-NPC binding, stabilizes cytoplasmic capsids, disrupts viral maturation, and demonstrates pan-stage antiviral efficacy and long-acting pharmacokinetics. Clinical trials have indicated its 100% prophylactic efficacy and potential to decrease global HIV incidence. Advances in structural biology, molecular dynamics simulations, and nanotechnology are expected to further inform next-generation therapeutic strategies targeting CA-host interactions. These findings not only redefine HIV-1 treatment paradigms but also have broader implications for combating CA-dependent viruses.<\/p>\n<p>Read full open access article at <a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0012\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0012<\/a><\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p><em>Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n<p><strong>Submission Process<\/strong><\/p>\n<p>Submissions <em>to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at <a href=\"https:\/\/mc04.manuscriptcentral.com\/ammed\">https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n<p>Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n<p>Please visit <a href=\"https:\/\/amm-journal.org\/\">https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/amm-journal.org\/index.php\/editorial-board\/\">https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Acta Materia Medica <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/AMM_journal\">https:\/\/twitter.com\/AMM_journal<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/AMMjournal\">https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7946<\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p>Mei Wang, Shujing Xu and Haiyong Jia et al. Revolutionizing HIV treatment: unveiling the new frontiers of HIV capsid research.\u00a0<em>Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(3):340-343. DOI: 10.15212\/AMM-2025-0012<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new publication for Acta Materia Medica journal. The HIV-1 capsid protein (CA) plays a crucial role in viral replication by orchestrating nuclear entry through interactions with host nuclear pore complexes (NPCs). Recent research has revealed that HIV-1 CA actively disrupts NPC architecture via phenylalanine-glycine (FG)-repeat nucleoporin interactions, thereby enabling nuclear translocation of viral [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":1493,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[378,477,478,479,480,481],"class_list":["post-1492","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-drug-design","tag-hiv-treatment","tag-hiv-1-capsid-protein","tag-lenacapavir","tag-nuclear-pore-complex","tag-nuclear-translocation"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Revolutionizing HIV treatment: unveiling the new frontiers of HIV capsid research<\/title>\n<meta name=\"description\" content=\"Revolutionizing HIV 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