{"id":1489,"date":"2025-05-15T12:15:02","date_gmt":"2025-05-15T12:15:02","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1489"},"modified":"2025-05-15T12:15:02","modified_gmt":"2025-05-15T12:15:02","slug":"discovery-of-wedelolactone","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/","title":{"rendered":"Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects"},"content":{"rendered":"<p>Announcing a new publication for <em>Acta Materia Medica<\/em> journal. Psoriasis is a chronic inflammatory disorder for which phosphodiesterase-4 (PDE4) inhibitors have emerged as promising therapeutic agents due to an ability to regulate inflammatory signaling pathways. In this study 1200 methanolic extracts from Chinese medicinal plants were screened and\u00a0<em>Eclipta prostrata<\/em>\u00a0(L.) Linn. (<em>E. prostrata<\/em>) was shown to have potent PDE4 inhibitory activity. Bioassay-guided fractionation further demonstrated that the ethyl acetate (EA) fraction exhibited the highest inhibitory activity, leading to the isolation of wedelolactone (WDL) as the principal bioactive compound (IC<sub>50<\/sub>\u00a0= 2.8 \u03bcM). Molecular dynamics simulations revealed that WDL forms stable interactions with PDE4D through hydrogen bonding and hydrophobic contacts.\u00a0<em>E. prostrata<\/em>-EA and WDL significantly suppressed pro-inflammatory cytokines in keratinocytes\u00a0<em>in vitro<\/em>. Topical application of WDL demonstrated superior anti-psoriatic efficacy compared to calcipotriol\u00a0<em>in vivo<\/em>, as evidenced by reduced Psoriasis Area and Severity Index scores, normalized epidermal thickness, and improved inflammatory cytokine profiles. WDL exhibited favorable metabolic stability in liver microsomes and demonstrated a good safety profile in subacute toxicity assessments with no systemic toxicity. These findings establish WDL as a potent and safe topical PDE4 inhibitor, highlighting the potential of WDL as a novel therapeutic candidate for psoriasis and warranting further clinical development.<\/p>\n<p>Read full open access article at <a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0017\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0017<\/a><\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p><em>Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n<p><strong>Submission Process<\/strong><\/p>\n<p>Submissions <em>to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at <a href=\"https:\/\/mc04.manuscriptcentral.com\/ammed\">https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n<p>Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n<p>Please visit <a href=\"https:\/\/amm-journal.org\/\">https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/amm-journal.org\/index.php\/editorial-board\/\">https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Acta Materia Medica <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/AMM_journal\">https:\/\/twitter.com\/AMM_journal<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/AMMjournal\">https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7946<\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p>Lingyu Wu, Yingying Wu and Shangding Yang et al. Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects.\u00a0<em>Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(3):344-357. DOI: 10.15212\/AMM-2025-0017<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new publication for Acta Materia Medica journal. Psoriasis is a chronic inflammatory disorder for which phosphodiesterase-4 (PDE4) inhibitors have emerged as promising therapeutic agents due to an ability to regulate inflammatory signaling pathways. In this study 1200 methanolic extracts from Chinese medicinal plants were screened and\u00a0Eclipta prostrata\u00a0(L.) Linn. (E. prostrata) was shown to [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":1490,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[473,476,475,464,474],"class_list":["post-1489","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-eclipta-prostrata-l-linn","tag-molecular-dynamics-simulation","tag-phosphodiesterase-4-inhibitor","tag-psoriasis","tag-wedelolactone"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects<\/title>\n<meta name=\"description\" content=\"Discover Wedelolactone (WDL), a natural PDE4 inhibitor from Eclipta prostrata. Safe, effective topical psoriasis therapy with clinical potential.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects\" \/>\n<meta property=\"og:description\" content=\"Discover Wedelolactone (WDL), a natural PDE4 inhibitor from Eclipta prostrata. Safe, effective topical psoriasis therapy with clinical potential.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/\" \/>\n<meta property=\"og:site_name\" content=\"AMM Journal\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-15T12:15:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Discovery-of-wedelolactone-from-Eclipta-Prostrata.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"628\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Suresh PDMR\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Suresh PDMR\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/\"},\"author\":{\"name\":\"Suresh PDMR\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\"},\"headline\":\"Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects\",\"datePublished\":\"2025-05-15T12:15:02+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/\"},\"wordCount\":378,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Discovery-of-wedelolactone-from-Eclipta-Prostrata.jpg\",\"keywords\":[\"Eclipta prostrata (L.) Linn.\",\"Molecular dynamics simulation\",\"Phosphodiesterase-4 inhibitor\",\"psoriasis\",\"Wedelolactone\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/\",\"name\":\"Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Discovery-of-wedelolactone-from-Eclipta-Prostrata.jpg\",\"datePublished\":\"2025-05-15T12:15:02+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\"},\"description\":\"Discover Wedelolactone (WDL), a natural PDE4 inhibitor from Eclipta prostrata. Safe, effective topical psoriasis therapy with clinical potential.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/#primaryimage\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Discovery-of-wedelolactone-from-Eclipta-Prostrata.jpg\",\"contentUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Discovery-of-wedelolactone-from-Eclipta-Prostrata.jpg\",\"width\":1200,\"height\":628,\"caption\":\"wedelolactone\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/05\\\/15\\\/discovery-of-wedelolactone\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/amm-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/\",\"name\":\"AMM Journal\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/amm-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\",\"name\":\"Suresh PDMR\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"caption\":\"Suresh PDMR\"},\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/author\\\/suresh\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects","description":"Discover Wedelolactone (WDL), a natural PDE4 inhibitor from Eclipta prostrata. Safe, effective topical psoriasis therapy with clinical potential.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/","og_locale":"en_GB","og_type":"article","og_title":"Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects","og_description":"Discover Wedelolactone (WDL), a natural PDE4 inhibitor from Eclipta prostrata. Safe, effective topical psoriasis therapy with clinical potential.","og_url":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/","og_site_name":"AMM Journal","article_published_time":"2025-05-15T12:15:02+00:00","og_image":[{"width":1200,"height":628,"url":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Discovery-of-wedelolactone-from-Eclipta-Prostrata.jpg","type":"image\/jpeg"}],"author":"Suresh PDMR","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Suresh PDMR","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/#article","isPartOf":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/"},"author":{"name":"Suresh PDMR","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e"},"headline":"Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects","datePublished":"2025-05-15T12:15:02+00:00","mainEntityOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/"},"wordCount":378,"commentCount":0,"image":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/#primaryimage"},"thumbnailUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Discovery-of-wedelolactone-from-Eclipta-Prostrata.jpg","keywords":["Eclipta prostrata (L.) Linn.","Molecular dynamics simulation","Phosphodiesterase-4 inhibitor","psoriasis","Wedelolactone"],"articleSection":["News and Events"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/","url":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/","name":"Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects","isPartOf":{"@id":"https:\/\/amm-journal.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/#primaryimage"},"image":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/#primaryimage"},"thumbnailUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Discovery-of-wedelolactone-from-Eclipta-Prostrata.jpg","datePublished":"2025-05-15T12:15:02+00:00","author":{"@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e"},"description":"Discover Wedelolactone (WDL), a natural PDE4 inhibitor from Eclipta prostrata. Safe, effective topical psoriasis therapy with clinical potential.","breadcrumb":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/#primaryimage","url":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Discovery-of-wedelolactone-from-Eclipta-Prostrata.jpg","contentUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/05\/Discovery-of-wedelolactone-from-Eclipta-Prostrata.jpg","width":1200,"height":628,"caption":"wedelolactone"},{"@type":"BreadcrumbList","@id":"https:\/\/amm-journal.org\/index.php\/2025\/05\/15\/discovery-of-wedelolactone\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/amm-journal.org\/"},{"@type":"ListItem","position":2,"name":"Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects"}]},{"@type":"WebSite","@id":"https:\/\/amm-journal.org\/#website","url":"https:\/\/amm-journal.org\/","name":"AMM Journal","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/amm-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e","name":"Suresh PDMR","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","caption":"Suresh PDMR"},"url":"https:\/\/amm-journal.org\/index.php\/author\/suresh\/"}]}},"_links":{"self":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1489","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=1489"}],"version-history":[{"count":1,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1489\/revisions"}],"predecessor-version":[{"id":1491,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1489\/revisions\/1491"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media\/1490"}],"wp:attachment":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=1489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=1489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=1489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}