{"id":1484,"date":"2025-05-09T09:37:47","date_gmt":"2025-05-09T09:37:47","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1484"},"modified":"2025-05-09T09:37:47","modified_gmt":"2025-05-09T09:37:47","slug":"pancreatic-cancer-chemotherapy","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/05\/09\/pancreatic-cancer-chemotherapy\/","title":{"rendered":"Boosting pancreatic cancer chemotherapy by disrupting nerve\u2013cancer crosstalk"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. A preclinical study has developed a precision nano-intervention strategy targeting tumor-associated nerves to destroy nerve-fueled tumor growth in pancreatic cancer. In this strategy,\u00a0Escherichia coli<\/em>\u00a0Nissle 1917-derived outer membrane vesicles (OMVs) are decorated with nerve-binding peptide for targeted delivery of co-loaded tropomyosin receptor kinase (Trk) inhibitors to tumor-associated nerves, thus precisely inhibiting nerve activity through the neurotrophin\/Trk signaling pathway. Furthermore, the OMVs trigger M2-M1 switching, thus accelerating nerve injury. This nano-intervention strategy significantly enhances chemotherapy efficacy in pancreatic cancer.<\/p>\n

Read full open access articles: https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2024-0092<\/a><\/p>\n

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Yutian Xia and Jianzhong Zhang. Boosting pancreatic cancer chemotherapy by disrupting nerve\u2013cancer crosstalk.\u00a0Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(3):317-320. DOI: 10.15212\/AMM-2024-0092<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. A preclinical study has developed a precision nano-intervention strategy targeting tumor-associated nerves to destroy nerve-fueled tumor growth in pancreatic cancer. In this strategy,\u00a0Escherichia coli\u00a0Nissle 1917-derived outer membrane vesicles (OMVs) are decorated with nerve-binding peptide for targeted delivery of co-loaded tropomyosin receptor kinase (Trk) inhibitors to tumor-associated […]<\/p>\n","protected":false},"author":5,"featured_media":1485,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[468,401,471,470,469,467,472],"class_list":["post-1484","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-biochemistry","tag-cancer-biology","tag-escherichia-coli","tag-pancreatic-cancer","tag-pancreatic-cancer-chemotherapy","tag-pharmaceutics","tag-tropomyosin-receptor-kinase"],"yoast_head":"\nBoosting pancreatic cancer chemotherapy by disrupting nerve\u2013cancer crosstalk<\/title>\n<meta name=\"description\" content=\"Innovative strategies in pancreatic cancer chemotherapy are 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