{"id":1449,"date":"2025-03-25T10:22:24","date_gmt":"2025-03-25T10:22:24","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1449"},"modified":"2025-03-25T10:22:24","modified_gmt":"2025-03-25T10:22:24","slug":"berberine-inhibits-phagocytosis","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/03\/25\/berberine-inhibits-phagocytosis\/","title":{"rendered":"Berberine inhibits phagocytosis through the TLR4-PI3K-CDC42 pathway"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal<\/a>. Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via phagocytosis inhibition, the authors of this article constructed a library of natural products and evaluated their ability to modulate phagocytosis in RAW264.7 macrophages.<\/p>\n

Berberine (BBR) is the major constituent of traditional Chinese medicine Coptidis Rhizoma that is recorded in Chinese Pharmacopoeia with the effect of clearing heat-toxin and is used in the therapeutic management of various inflammatory diseases. BBR was found to inhibit phagocytosis and significantly alleviate inflammation via suppressing interleukin-1\u03b1 (IL-1\u03b1), interleukin-1\u03b2 (IL-1\u03b2), inducible nitric oxide synthase (iNOS), and tumor necrosis factor-\u03b1 (TNF-\u03b1), according to real-time quantitative polymerase chain reaction (RT-qPCR) analyses, and phosphorylated-p65 (p-p65), iNOS, and cyclooxygenase-2 (COX-2), according to western blot analyses.<\/p>\n

BBR inhibited the expression of F-actin, a key protein in phagosome formation. Notably, BBR exerted its phagocytosis effects through targeting phosphoinositide 3-kinase (PI3K), thereby activating the small GTPase-Cdc42 (CDC42), Wiskott-Aldrich syndrome protein (WASP), and actin-related protein 2\/3 complex subunit 2 (Arp2\/3). BBR attenuated LPS-mediated inflammation through promoting macrophage phagocytosis. It was determined that BBR targets the toll-like receptor 4 (TLR4)-PI3K-CDC42 pathway, thereby inhibiting the nuclear factor-kappa B (NF-\u03baB) pathway, and consequently regulating phagocytosis and the inflammatory response. These findings suggest that BBR might serve as a candidate for the development of phagocytic inhibitors.<\/p>\n

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Jing Chang, Chengpeng Sun and Miaomiao Wang et al. Berberine inhibits phagocytosis through the TLR4-PI3K-CDC42 pathway.\u00a0Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(2):280-292. DOI: 10.15212\/AMM-2024-0074<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via phagocytosis inhibition, the authors of this article constructed a library of natural products and evaluated their ability to modulate phagocytosis in […]<\/p>\n","protected":false},"author":5,"featured_media":1450,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[390,460,461],"class_list":["post-1449","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-berberine","tag-phagocytosis","tag-tlr4-pi3k-cdc42"],"yoast_head":"\nBerberine inhibits phagocytosis through the TLR4-PI3K-CDC42 pathway<\/title>\n<meta name=\"description\" content=\"Berberine inhibits phagocytosis and inflammation via the TLR4-PI3K-CDC42 pathway, suppressing NF-\u03baB signaling and key inflammatory markers in macrophages.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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