{"id":1440,"date":"2025-03-11T14:21:16","date_gmt":"2025-03-11T14:21:16","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1440"},"modified":"2025-03-11T14:21:16","modified_gmt":"2025-03-11T14:21:16","slug":"supramolecular-photosensitizer-for-cancer-therapy","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/","title":{"rendered":"Natural supramolecular photosensitizer with in situ switchable photothermal\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal<\/a>. Treatment of cancer can be challenging, because of the disease\u2019s intricate and varied nature. Consequently, developing nanomedicines with multimodal therapeutic capabilities for precise tumor therapy holds substantial promise in advancing cancer treatment. Herein, a nanoplatform strategy involving supramolecular photosensitizer (ETSCe6 NPs) and chelated metal ions (Au and Bi) was found to induce a shift in tumor microenvironment responsiveness from photothermal therapy to photodynamic therapy, thus facilitating tumor visualization for precise diagnosis and treatment.<\/p>\n

Self-assembly of supramolecular photosensitizers enhanced photothermal therapy through aggregation-caused quenching. Moreover, glutathione triggered disulfide bond cleavage, and consequently Ergosterol (ET) and Chlorin e6 release. Therefore, chemotherapy and photodynamic therapy achieved synergistic anticancer effects. Ce6 cavities were also used to chelate high valence Au and Bi metal ions for computed tomography.<\/p>\n

The ETSCe6@Au, Bi NPs demonstrated remarkable efficacy\u00a0in vitro<\/em>\u00a0and\u00a0in vivo<\/em>, achieving complete tumor elimination after treatment. This integrated approach combining imaging, chemotherapy, photodynamic, and photothermal therapies has substantial promise for clinical applications, and may provide an innovative strategy for developing intelligent nanomedicines with promising prospects.<\/p>\n

Read More:\u00a0https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2024-0081<\/a><\/p>\n

Acta Materia Medica<\/em><\/a> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n

Submission Process<\/strong><\/p>\n

Submissions to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n

Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n

Please visit https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n

Editorial Board:<\/strong> https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n

There are no author submission or article processing fees.<\/p>\n

Follow Acta Materia Medica <\/em><\/strong>on Twitter https:\/\/twitter.com\/AMM_journal<\/a>; Facebook<\/a> (https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n

eISSN <\/strong>2737-7946<\/p>\n

Shiyao Fu, Jianjun Cheng and Hua Zhang et al. Natural supramolecular photosensitizer with in situ switchable photothermal\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy.\u00a0Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(2):233-249. DOI: 10.15212\/AMM-2024-0081<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Treatment of cancer can be challenging, because of the disease\u2019s intricate and varied nature. Consequently, developing nanomedicines with multimodal therapeutic capabilities for precise tumor therapy holds substantial promise in advancing cancer treatment. Herein, a nanoplatform strategy involving supramolecular photosensitizer (ETSCe6 NPs) and chelated metal ions (Au […]<\/p>\n","protected":false},"author":5,"featured_media":1441,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[457,79,456,116,459,458],"class_list":["post-1440","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-aggregation-caused-quenching","tag-cancer-therapy","tag-natural-small-molecules","tag-photodynamic-therapy","tag-supramolecular-photosensitizer","tag-synergistic-cancer-treatment"],"yoast_head":"\nNatural supramolecular photosensitizer with in situ switchable photothermal\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy<\/title>\n<meta name=\"description\" content=\"A nanoplatform with Supramolecular photosensitizer and metal ions enables tumor imaging and multimodal therapy, achieving complete tumor elimination in preclinical studies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Natural supramolecular photosensitizer with in situ switchable photothermal\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy\" \/>\n<meta property=\"og:description\" content=\"A nanoplatform with Supramolecular photosensitizer and metal ions enables tumor imaging and multimodal therapy, achieving complete tumor elimination in preclinical studies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/\" \/>\n<meta property=\"og:site_name\" content=\"AMM Journal\" \/>\n<meta property=\"article:published_time\" content=\"2025-03-11T14:21:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/03\/Natural-supramolecular-photosensitizer-FB.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"628\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Suresh PDMR\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Suresh PDMR\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/\"},\"author\":{\"name\":\"Suresh PDMR\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\"},\"headline\":\"Natural supramolecular photosensitizer with in situ switchable photothermal\\\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy\",\"datePublished\":\"2025-03-11T14:21:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/\"},\"wordCount\":361,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Natural-supramolecular-photosensitizer-FB.png\",\"keywords\":[\"Aggregation-caused quenching\",\"cancer therapy\",\"Natural small molecules\",\"photodynamic therapy\",\"Supramolecular photosensitizer\",\"Synergistic cancer treatment\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/\",\"name\":\"Natural supramolecular photosensitizer with in situ switchable photothermal\\\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Natural-supramolecular-photosensitizer-FB.png\",\"datePublished\":\"2025-03-11T14:21:16+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\"},\"description\":\"A nanoplatform with Supramolecular photosensitizer and metal ions enables tumor imaging and multimodal therapy, achieving complete tumor elimination in preclinical studies.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/#primaryimage\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Natural-supramolecular-photosensitizer-FB.png\",\"contentUrl\":\"https:\\\/\\\/amm-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Natural-supramolecular-photosensitizer-FB.png\",\"width\":1200,\"height\":628},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2025\\\/03\\\/11\\\/supramolecular-photosensitizer-for-cancer-therapy\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/amm-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Natural supramolecular photosensitizer with in situ switchable photothermal\\\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/\",\"name\":\"AMM Journal\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/amm-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/36ab5fda177218467d112d0c1283065e\",\"name\":\"Suresh PDMR\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g\",\"caption\":\"Suresh PDMR\"},\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/author\\\/suresh\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Natural supramolecular photosensitizer with in situ switchable photothermal\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy","description":"A nanoplatform with Supramolecular photosensitizer and metal ions enables tumor imaging and multimodal therapy, achieving complete tumor elimination in preclinical studies.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/","og_locale":"en_GB","og_type":"article","og_title":"Natural supramolecular photosensitizer with in situ switchable photothermal\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy","og_description":"A nanoplatform with Supramolecular photosensitizer and metal ions enables tumor imaging and multimodal therapy, achieving complete tumor elimination in preclinical studies.","og_url":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/","og_site_name":"AMM Journal","article_published_time":"2025-03-11T14:21:16+00:00","og_image":[{"width":1200,"height":628,"url":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/03\/Natural-supramolecular-photosensitizer-FB.png","type":"image\/png"}],"author":"Suresh PDMR","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Suresh PDMR","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/#article","isPartOf":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/"},"author":{"name":"Suresh PDMR","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e"},"headline":"Natural supramolecular photosensitizer with in situ switchable photothermal\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy","datePublished":"2025-03-11T14:21:16+00:00","mainEntityOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/"},"wordCount":361,"commentCount":0,"image":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/#primaryimage"},"thumbnailUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/03\/Natural-supramolecular-photosensitizer-FB.png","keywords":["Aggregation-caused quenching","cancer therapy","Natural small molecules","photodynamic therapy","Supramolecular photosensitizer","Synergistic cancer treatment"],"articleSection":["News and Events"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/","url":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/","name":"Natural supramolecular photosensitizer with in situ switchable photothermal\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy","isPartOf":{"@id":"https:\/\/amm-journal.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/#primaryimage"},"image":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/#primaryimage"},"thumbnailUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/03\/Natural-supramolecular-photosensitizer-FB.png","datePublished":"2025-03-11T14:21:16+00:00","author":{"@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e"},"description":"A nanoplatform with Supramolecular photosensitizer and metal ions enables tumor imaging and multimodal therapy, achieving complete tumor elimination in preclinical studies.","breadcrumb":{"@id":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/#primaryimage","url":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/03\/Natural-supramolecular-photosensitizer-FB.png","contentUrl":"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/03\/Natural-supramolecular-photosensitizer-FB.png","width":1200,"height":628},{"@type":"BreadcrumbList","@id":"https:\/\/amm-journal.org\/index.php\/2025\/03\/11\/supramolecular-photosensitizer-for-cancer-therapy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/amm-journal.org\/"},{"@type":"ListItem","position":2,"name":"Natural supramolecular photosensitizer with in situ switchable photothermal\/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy"}]},{"@type":"WebSite","@id":"https:\/\/amm-journal.org\/#website","url":"https:\/\/amm-journal.org\/","name":"AMM Journal","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/amm-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/36ab5fda177218467d112d0c1283065e","name":"Suresh PDMR","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/78f026916ecafc09393a244fb16a944cf7ed125822beafb24d190ab4192ca56c?s=96&d=mm&r=g","caption":"Suresh PDMR"},"url":"https:\/\/amm-journal.org\/index.php\/author\/suresh\/"}]}},"_links":{"self":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1440","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=1440"}],"version-history":[{"count":1,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1440\/revisions"}],"predecessor-version":[{"id":1442,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1440\/revisions\/1442"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media\/1441"}],"wp:attachment":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=1440"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=1440"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=1440"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}