{"id":1427,"date":"2025-02-27T11:19:22","date_gmt":"2025-02-27T11:19:22","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1427"},"modified":"2025-02-27T11:19:22","modified_gmt":"2025-02-27T11:19:22","slug":"cordyceps-sinensis-mycelium","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/02\/27\/cordyceps-sinensis-mycelium\/","title":{"rendered":"Randomized, waitlist-controlled trial of Cordyceps sinensis mycelium culture extract (Cs4) for long COVID patients in Hong Kong"},"content":{"rendered":"<p>Announcing a new publication for <a href=\"https:\/\/amm-journal.org\/\"><em>Acta Materia Medica<\/em> journal<\/a>. <em>Cordyceps sinensis<\/em>\u00a0mycelium culture extract (Cs4) were assessed for alleviating long COVID symptoms. In this randomized trial 110 participants were assigned to receive Cs4 (55 participants) or were waitlisted (55 participants) for 12 weeks. The primary outcome was the change in long COVID symptom severity at 12 weeks, as measured by the modified COVID-19 Yorkshire Rehabilitation Scale.<\/p>\n<p>The secondary outcomes included changes in the Brief Fatigue Inventory Form, Insomnia Severity Index, Hospital Anxiety and Depression Scale, St. George\u2019s Respiratory Questionnaire, and the Short Form 12 health survey at 12 weeks. Participants receiving Cs4 showed improvement in long COVID symptoms compared to the waitlist control group (MD, \u221210.1; 95% CI, \u221214.1 to \u22126.1;\u00a0<em>P<\/em>\u00a0&lt; 0.001) at 12 weeks. Cs4 recipients also experienced improvement in fatigue (MD, \u22128.1; 95% CI, \u221214.2 to \u22122.0;\u00a0<em>P<\/em>\u00a0= 0.011), insomnia (MD, \u22122.9; 95% CI, \u22124.6 to \u22121.2;\u00a0<em>P<\/em>\u00a0= 0.001), and respiratory symptoms (MD, \u22126.3; 95% CI, \u221211.4 to \u22121.2;\u00a0<em>P<\/em>\u00a0= 0.018).<\/p>\n<p>Cs4 also improved the quality of life (physical component MD, 7.0; 95% CI, 4.2\u20139.8;\u00a0<em>P<\/em>\u00a0&lt; 0.001; mental component MD, 6.8; 95% CI, 2.9\u201310.7;\u00a0<em>P<\/em>\u00a0&lt; 0.001). No severe adverse events were reported. Cs4 may be a beneficial treatment for patients with long COVID symptoms.<\/p>\n<p>Read More: <a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2024-0089\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2024-0089<\/a><\/p>\n<p><em>Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n<p><strong>Submission Process<\/strong><\/p>\n<p>Submissions <em>to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at <a href=\"https:\/\/mc04.manuscriptcentral.com\/ammed\">https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n<p>Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n<p>Please visit <a href=\"https:\/\/amm-journal.org\/\">https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/amm-journal.org\/index.php\/editorial-board\/\">https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Acta Materia Medica <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/AMM_journal\">https:\/\/twitter.com\/AMM_journal<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/AMMjournal\">https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7946<\/p>\n<p>Yuanyuan Chen, Guang Chen and Cheng Zhang et al. Randomized, waitlist-controlled trial of Cordyceps sinensis mycelium culture extract (Cs4) for long COVID patients in Hong Kong.\u00a0<em>Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(2):250-261. DOI: 10.15212\/AMM-2024-0089<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new publication for Acta Materia Medica journal. Cordyceps sinensis\u00a0mycelium culture extract (Cs4) were assessed for alleviating long COVID symptoms. In this randomized trial 110 participants were assigned to receive Cs4 (55 participants) or were waitlisted (55 participants) for 12 weeks. The primary outcome was the change in long COVID symptom severity at 12 [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":1428,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[448,449,447,451,450,452],"class_list":["post-1427","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-cordyceps-sinensis-berk-sacc","tag-cs4","tag-long-covid","tag-modified-covid-19","tag-randomized-trial","tag-yorkshire-rehabilitation-scale-c19-yrsm"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Randomized, waitlist-controlled trial of Cordyceps sinensis mycelium culture extract (Cs4) for long COVID patients in Hong Kong<\/title>\n<meta name=\"description\" content=\"Cordyceps sinensis\u00a0mycelium culture extract (Cs4) were assessed for alleviating long COVID symptoms. 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