{"id":1375,"date":"2025-02-05T09:13:36","date_gmt":"2025-02-05T09:13:36","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1375"},"modified":"2025-02-05T09:13:36","modified_gmt":"2025-02-05T09:13:36","slug":"protac-technology-for-prostate-cancer-treatment","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/02\/05\/protac-technology-for-prostate-cancer-treatment\/","title":{"rendered":"PROTAC technology for prostate cancer treatment"},"content":{"rendered":"<p>Announcing a new publication for <em>Acta Materia Medica<\/em> journal. Prostate cancer (PrCa) is the most prevalent urogenital cancer affecting men. PrCa is marked by uncontrolled cellular growth that leads to abnormal enlargement of the prostate gland. The metastatic spread of PrCa is the primary cause of mortality, causing cancer cell dissemination to distant sites, such as bones, the pelvis, and various visceral organs. Key contributors to PrCa progression include genetic mutations, elevated androgen receptor expression, gene amplification, and the rise of androgen receptor splice variants. Although androgen deprivation therapy remains the mainstay for early-stage PrCa treatment, efficacy is temporary because many cases advance to castration-resistant PrCa (CRPC), presenting a significant therapeutic hurdle. This review explores key biomarkers for PrCa and the latest therapeutic strategies for CRPC with a particular focus on the innovative proteolysis-targeting chimera (PROTAC) technology. This approach offers a novel means of degrading target proteins and we discuss how PROTAC holds potential as effective strategies to combat resistance mechanisms in CRPC.<\/p>\n<p>Read full open-access articles at https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2024-0075<\/p>\n<p><em>Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n<p><strong>Submission Process<\/strong><\/p>\n<p>Submissions <em>to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at <a href=\"https:\/\/mc04.manuscriptcentral.com\/ammed\">https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n<p>Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n<p>Please visit <a href=\"https:\/\/amm-journal.org\/\">https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/amm-journal.org\/index.php\/editorial-board\/\">https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Acta Materia Medica <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/AMM_journal\">https:\/\/twitter.com\/AMM_journal<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/AMMjournal\">https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7946<\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p>Zhen Wang, Dingpeng Zhang and Hiroyuki Inuzuka et al. PROTAC technology for prostate cancer treatment.\u00a0<em>Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(1):99-121. DOI: 10.15212\/AMM-2024-0075<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new publication for Acta Materia Medica journal. Prostate cancer (PrCa) is the most prevalent urogenital cancer affecting men. PrCa is marked by uncontrolled cellular growth that leads to abnormal enlargement of the prostate gland. The metastatic spread of PrCa is the primary cause of mortality, causing cancer cell dissemination to distant sites, such [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":1376,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[401,400,211,399,13],"class_list":["post-1375","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-cancer-biology","tag-chemical-biology","tag-prostate-cancer","tag-prostate-cancer-treatment","tag-protac"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PROTAC technology for prostate cancer treatment<\/title>\n<meta name=\"description\" content=\"Explore key biomarkers and novel therapies for prostate cancer treatment, including PROTAC technology, offering hope for overcoming castration-resistant PrCa.\" 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