{"id":1364,"date":"2025-01-22T07:33:03","date_gmt":"2025-01-22T07:33:03","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1364"},"modified":"2025-01-22T07:33:03","modified_gmt":"2025-01-22T07:33:03","slug":"epithelial-cell-adhesion-molecule","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/01\/22\/epithelial-cell-adhesion-molecule\/","title":{"rendered":"Arenobufagin suppresses the progression of early-stage hepatocellular carcinoma by inhibiting EpCAM-mediated tumor stemness"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal<\/a>. Epithelial cell adhesion molecule (EpCAM) is a biomarker for epithelial cell-derived tumors. However, the specific role of EpCAM itself in early-stage hepatocellular carcinoma progression remains unclear, and small molecules targeting EpCAM have not yet been reported.<\/p>\n

This article discusses how the protein expression profile of EpCAM in tumor-adjacent regions was found to be higher than that in tumor regions, and to be positively associated with the progression of early-stage liver cancer, as well as high frequency of recurrence, cirrhosis, lymph node metastasis, microvascular invasion and cancer stemness, in 68 patients with hepatocellular carcinoma (HCC).<\/p>\n

In vitro<\/em>, EpCAM enhanced cancer cell stemness, as reflected by increased abilities of proliferation, self-renewal, migration and invasion, which was counteracted by arenobufagin. Furthermore, arenobufagin inhibited the viability of Hep3B and Huh7 cells with IC50<\/sub>\u00a0values of 36.4 nM and 123.4 nM after 72 h of treatment, respectively. Molecular docking data further indicated that arenobufagin binds EpCAM.<\/p>\n

Moreover, arenobufagin inhibited early progression of HCC through EpCAM in a zebrafish xenograft tumor model mimicking early-stage hepatocellular carcinoma without blood vessels\u00a0in vivo<\/em>. This study supports a tumor-promoting role of EpCAM in early-stage hepatocellular carcinoma by facilitating cancer stemness and suggests that arenobufagin might be promising candidate for EpCAM inhibition.<\/p>\n

Read More:\u00a0https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2024-0064<\/a><\/p>\n

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Lijuan Deng, Lifang Zou and Chunhong Zhou et al. Arenobufagin suppresses the progression of early-stage hepatocellular carcinoma by inhibiting EpCAM-mediated tumor stemness.\u00a0Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(1):82-98. DOI: 10.15212\/AMM-2024-0064<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Epithelial cell adhesion molecule (EpCAM) is a biomarker for epithelial cell-derived tumors. However, the specific role of EpCAM itself in early-stage hepatocellular carcinoma progression remains unclear, and small molecules targeting EpCAM have not yet been reported. This article discusses how the protein expression profile of EpCAM […]<\/p>\n","protected":false},"author":5,"featured_media":1365,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[396,397,395,398],"class_list":["post-1364","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-arenobufagin","tag-cancer-stemness","tag-early-stage-hepatocellular-carcinoma","tag-epithelial-cell-adhesion-molecule"],"yoast_head":"\nArenobufagin suppresses the progression of early-stage hepatocellular carcinoma by inhibiting EpCAM-mediated tumor stemness<\/title>\n<meta name=\"description\" content=\"EpCAM promotes cancer stemness and early-stage HCC progression, counteracted by arenobufagin, a potential therapeutic targeting EpCAM.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2025\/01\/22\/epithelial-cell-adhesion-molecule\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Arenobufagin suppresses the progression of early-stage hepatocellular carcinoma by inhibiting EpCAM-mediated tumor stemness\" \/>\n<meta property=\"og:description\" content=\"EpCAM promotes cancer stemness and early-stage HCC progression, counteracted by arenobufagin, a potential therapeutic targeting EpCAM.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/amm-journal.org\/index.php\/2025\/01\/22\/epithelial-cell-adhesion-molecule\/\" \/>\n<meta property=\"og:site_name\" content=\"AMM Journal\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-22T07:33:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/amm-journal.org\/wp-content\/uploads\/2025\/01\/amm20240064_ga1.jpg\" \/>\n\t<meta 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