{"id":1329,"date":"2025-01-09T06:22:09","date_gmt":"2025-01-09T06:22:09","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1329"},"modified":"2025-01-09T06:22:09","modified_gmt":"2025-01-09T06:22:09","slug":"als-drug-discovery","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/01\/09\/als-drug-discovery\/","title":{"rendered":"Patient-derived induced pluripotent stem cell organoids for amyotrophic lateral sclerosis drug discovery"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal<\/a>. Complex biological mechanisms and unidentified therapeutic targets for amyotrophic lateral sclerosis (ALS) significantly hinder the development of effective treatments. Given these challenges, reliable disease models that accurately replicate ALS phenotypes with relevant biological underpinnings are essential for advancing precision medicine in ALS.<\/p>\n

Patient-derived induced pluripotent stem cell (iPSC) organoids have emerged as an innovative tool for disease modeling and drug evaluation. Growing evidence highlights the advantages of organoids in replicating ALS phenotypes and supporting drug development. However, challenges remain in utilizing organoids for ALS drug testing and other neurodegenerative diseases.<\/p>\n

In this review the current progress in ALS model development are summarized, encompassing both\u00a0in vitro<\/em>\u00a0and\u00a0in vivo<\/em>\u00a0non-human models, as well as iPSC-derived human models. Furthermore, within the context of ALS drug screening, critical considerations for applying organoids to evaluate disease-associated phenotypes and to accurately reflect disease-related symptoms are discussed.<\/p>\n

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eISSN <\/strong>2737-7946<\/p>\n

Wenyan Li, Jinqi Liu and Wenting Li et al. Patient-derived induced pluripotent stem cell organoids for amyotrophic lateral sclerosis drug discovery.\u00a0Acta Materia Medica.\u00a0<\/em>2025. Vol. 3(4):556-570. DOI: 10.15212\/AMM-2024-0077<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Complex biological mechanisms and unidentified therapeutic targets for amyotrophic lateral sclerosis (ALS) significantly hinder the development of effective treatments. Given these challenges, reliable disease models that accurately replicate ALS phenotypes with relevant biological underpinnings are essential for advancing precision medicine in ALS. Patient-derived induced pluripotent stem […]<\/p>\n","protected":false},"author":5,"featured_media":1330,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[386,382,383,385,384],"class_list":["post-1329","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-als-drug-discovery","tag-amyotrophic-lateral-sclerosis","tag-disease-models","tag-high-throughput-screening","tag-organoids"],"yoast_head":"\nPatient-derived induced pluripotent stem cell organoids for amyotrophic lateral sclerosis drug discovery<\/title>\n<meta name=\"description\" content=\"Explore amyotrophic lateral sclerosis drug discovery with patient-derived iPSC organoids, highlighting advances, challenges, and their role in replicating ALS phenotypes\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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