{"id":1238,"date":"2024-12-16T08:23:14","date_gmt":"2024-12-16T08:23:14","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1238"},"modified":"2024-12-16T08:24:38","modified_gmt":"2024-12-16T08:24:38","slug":"mechanism-of-action-of-neocryptolepine-and-its-derivatives","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2024\/12\/16\/mechanism-of-action-of-neocryptolepine-and-its-derivatives\/","title":{"rendered":"Research advances in anti-cancer activities and mechanism of action of neocryptolepine and its derivatives"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal<\/a>. Cancer has been a severe public health and social problem, a leading disease that has diminished the quality of life, and a barrier to improving life expectancy. Neocryptolepine is an indole-quinoline alkaloid isolated from\u00a0Cryptolepis sanguinolenta<\/em>\u00a0which grows in some African countries.<\/p>\n

This article summarizes the structures of 228 neocryptolepine derivatives, including 84 neocryptolepine derivatives synthesized by our laboratory, and analyzed the cytotoxic effects and mechanism of action at the cellular level. Neocryptolepine derivatives\u00a043<\/strong>,\u00a065<\/strong>,\u00a093<\/strong>, and\u00a096<\/strong>\u00a0have good cytotoxicity against gastric cancer AGS cells and the IC50<\/sub>\u00a0value reached 43 nM, 148 nM, 2.9 \u03bcM, and 4.5 \u03bcM, respectively. The IC50<\/sub>\u00a0values of compounds\u00a064<\/strong>\u00a0and\u00a069<\/strong>\u00a0on colorectal cancer HCT116 cells reached 0.33 and 0.35 \u03bcM, respectively.<\/p>\n

The structure-activity relationship of these compounds is discussed; Topoisomerase II is discussed as a possible inhibition target of neocryptolepine derivatives in several cancer cell lines by binding DNA. The structures of the reported neocryptolepine derivatives and the possible cytotoxic mechanisms are analyzed. This review provides a fundamental reference for anticancer drug development of neocryptolepine and its derivatives as anti-tumor agents.<\/p>\n

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Yunhao Ma, Zhongkun Zhou and Lixue Tu et al. Research advances in anti-cancer activities and mechanism of action of neocryptolepine and its derivatives.\u00a0Acta Materia Medica.\u00a0<\/em>2024. Vol. 3(4):436-461. DOI: 10.15212\/AMM-2024-0054<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Cancer has been a severe public health and social problem, a leading disease that has diminished the quality of life, and a barrier to improving life expectancy. Neocryptolepine is an indole-quinoline alkaloid isolated from\u00a0Cryptolepis sanguinolenta\u00a0which grows in some African countries. This article summarizes the structures of […]<\/p>\n","protected":false},"author":5,"featured_media":1239,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[352,354,353,79,123,350,349,355,351],"class_list":["post-1238","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-alkaloid","tag-anti-tumor-agents","tag-cancer-research","tag-cancer-therapy","tag-cancer-treatment","tag-cryptolepis-sanguinolenta","tag-neocryptolepine","tag-neocryptolepine-derivatives","tag-public-health"],"yoast_head":"\nResearch advances in anti-cancer activities and mechanism of action of neocryptolepine and its derivatives<\/title>\n<meta name=\"description\" content=\"Discover the anti-cancer potential of neocryptolepine derivatives, their mechanisms, and key compounds for developing effective anti-tumor therapies\" \/>\n<meta name=\"robots\" content=\"index, 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