{"id":1197,"date":"2024-11-05T15:33:20","date_gmt":"2024-11-05T15:33:20","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1197"},"modified":"2024-11-05T15:33:20","modified_gmt":"2024-11-05T15:33:20","slug":"druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/","title":{"rendered":"Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. \u00a0Celastrol is an active compound from the root of\u00a0Tripterygium wilfordii<\/em>\u00a0Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hindered by its low bioavailability and severe systemic toxicity.<\/p>\n

The aim of this review article was to discuss the druggability, molecular targets, and nanocarrier delivery of the natural triterpenoid, celastrol, against chronic diseases. The physicochemical properties of celastrol were sequentially investigated using online tools (pkCSM and SwissADME), the recent studies on the molecular mechanisms underlying the therapeutic effects of celastrol were reviewed, and the potential of nanoparticle-mediated delivery systems for safe and effective delivery of celastrol were examined. The cancer-related targets and pathways involved were further predicted through network pharmacologic analysis.<\/p>\n

This review provides molecular insights into the pharmacologic activities and molecular mechanisms underlying celastrol, as well as useful information for the selection of nanocarrier drug delivery system for the clinical delivery of celastrol against various chronic diseases.<\/p>\n

Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n

https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2024-0044<\/a><\/p>\n

Submission Process<\/strong><\/p>\n

Submissions to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n

Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n

Please visit https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n

Editorial Board:<\/strong> https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n

There are no author submission or article processing fees.<\/p>\n

Follow Acta Materia Medica <\/em><\/strong>on Twitter https:\/\/twitter.com\/AMM_journal<\/a>; Facebook<\/a> (https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n

eISSN <\/strong>2737-7946<\/p>\n

Chi Lui Chan, Yilu Sun and Xiaowen Mao et al. Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases.\u00a0Acta Materia Medica.\u00a0<\/em>2024. Vol. 3(4):383-404. DOI: 10.15212\/AMM-2024-0044<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. \u00a0Celastrol is an active compound from the root of\u00a0Tripterygium wilfordii\u00a0Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hindered by its low bioavailability and severe systemic toxicity. The aim of this […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[187,338,48,167,339,340],"class_list":["post-1197","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-cancer","tag-celastrol","tag-diabetes","tag-inflammation","tag-neurodegeneration","tag-obesity"],"yoast_head":"\nDruggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. \u00a0Celastrol is an active compound from the root of\u00a0Tripterygium wilfordii\u00a0Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hindered by its low bioavailability and severe systemic toxicity. The aim of this […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/\" \/>\n<meta property=\"og:site_name\" content=\"AMM Journal\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-05T15:33:20+00:00\" \/>\n<meta name=\"author\" content=\"Compuscript\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Compuscript\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/11\\\/05\\\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/11\\\/05\\\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\\\/\"},\"author\":{\"name\":\"Compuscript\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\"},\"headline\":\"Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases\",\"datePublished\":\"2024-11-05T15:33:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/11\\\/05\\\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\\\/\"},\"wordCount\":335,\"commentCount\":0,\"keywords\":[\"cancer\",\"Celastrol\",\"diabetes\",\"inflammation\",\"neurodegeneration\",\"obesity\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/11\\\/05\\\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/11\\\/05\\\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\\\/\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/11\\\/05\\\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\\\/\",\"name\":\"Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases - AMM Journal\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\"},\"datePublished\":\"2024-11-05T15:33:20+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/11\\\/05\\\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/11\\\/05\\\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/11\\\/05\\\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/amm-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/\",\"name\":\"AMM Journal\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/amm-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\",\"name\":\"Compuscript\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"caption\":\"Compuscript\"},\"sameAs\":[\"https:\\\/\\\/amm-journal.org\"],\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/author\\\/ammjadmin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases - AMM Journal","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/","og_locale":"en_GB","og_type":"article","og_title":"Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases - AMM Journal","og_description":"Announcing a new publication for Acta Materia Medica journal. \u00a0Celastrol is an active compound from the root of\u00a0Tripterygium wilfordii\u00a0Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hindered by its low bioavailability and severe systemic toxicity. The aim of this […]","og_url":"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/","og_site_name":"AMM Journal","article_published_time":"2024-11-05T15:33:20+00:00","author":"Compuscript","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Compuscript","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/#article","isPartOf":{"@id":"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/"},"author":{"name":"Compuscript","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67"},"headline":"Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases","datePublished":"2024-11-05T15:33:20+00:00","mainEntityOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/"},"wordCount":335,"commentCount":0,"keywords":["cancer","Celastrol","diabetes","inflammation","neurodegeneration","obesity"],"articleSection":["News and Events"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/","url":"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/","name":"Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases - AMM Journal","isPartOf":{"@id":"https:\/\/amm-journal.org\/#website"},"datePublished":"2024-11-05T15:33:20+00:00","author":{"@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67"},"breadcrumb":{"@id":"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/amm-journal.org\/index.php\/2024\/11\/05\/druggability-molecular-targets-and-nanocarrier-delivery-of-natural-triterpenoid-celastrol-against-chronic-diseases\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/amm-journal.org\/"},{"@type":"ListItem","position":2,"name":"Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases"}]},{"@type":"WebSite","@id":"https:\/\/amm-journal.org\/#website","url":"https:\/\/amm-journal.org\/","name":"AMM Journal","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/amm-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67","name":"Compuscript","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","caption":"Compuscript"},"sameAs":["https:\/\/amm-journal.org"],"url":"https:\/\/amm-journal.org\/index.php\/author\/ammjadmin\/"}]}},"_links":{"self":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=1197"}],"version-history":[{"count":1,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1197\/revisions"}],"predecessor-version":[{"id":1198,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1197\/revisions\/1198"}],"wp:attachment":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=1197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=1197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=1197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}