{"id":1116,"date":"2024-06-21T08:07:31","date_gmt":"2024-06-21T08:07:31","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1116"},"modified":"2024-06-21T08:07:31","modified_gmt":"2024-06-21T08:07:31","slug":"development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/","title":{"rendered":"Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. Ulcerative colitis (UC) is a chronic intestinal disorder characterized by severe intestinal inflammation and superficial mucosal ulcers. Ramulus mori alkaloids (SZ-A) were approved by the National Medical Products Administration of China in 2020 for the treatment of type 2 diabetes mellitus. Later studies confirmed that SZ-A act on multiple inflammatory pathways to exert anti-inflammatory effects, suggesting that SZ-A has the potential to alleviate UC. A temperature-sensitive hydrogel embedded with sodium alginate (SA)-chitosan (CS) microspheres was constructed for colon-targeted delivery of SZ-A. The results showed that the microspheres prepared by exogenous emulsification had rounded and smooth surfaces with high drug-loading capacity. The optimum preparation conditions were as follows: 600 rpm stirring speed; a 1:4 ratio of water-to-oil phase; and a 5% Span80 emulsifier. The temperature-sensitive hydrogels embedded with SA-CS microspheres (TMH) had a moderate gelling temperature of 31.8 \u00b1 0.74\u00b0C. The rheologic results showed that the internal structure of TMH was stable with viscoelasticity, and the\u00a0in vitro<\/em>\u00a0release results indicated that the TMH exhibited slow-release performance. The findings suggest that TMH has suitable gelling temperature and viscoelasticity, and may be a promising targeted delivery vector for UC treatment.<\/p>\n

https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2024-0017<\/a><\/p>\n

Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n

Submission Process<\/strong><\/p>\n

Submissions to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n

Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n

Please visit https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n

Editorial Board:<\/strong> https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n

There are no author submission or article processing fees.<\/p>\n

Follow Acta Materia Medica <\/em><\/strong>on Twitter https:\/\/twitter.com\/AMM_journal<\/a>; Facebook<\/a> (https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n

eISSN <\/strong>2737-7946<\/p>\n

Yu Yan, Xinrui Zhang and Xiaoyan Xu et al. Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres.\u00a0Acta Materia Medica.\u00a0<\/em>2024. Vol. 3(2):226-238. DOI: 10.15212\/AMM-2024-0017<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Ulcerative colitis (UC) is a chronic intestinal disorder characterized by severe intestinal inflammation and superficial mucosal ulcers. Ramulus mori alkaloids (SZ-A) were approved by the National Medical Products Administration of China in 2020 for the treatment of type 2 diabetes mellitus. Later studies confirmed that SZ-A […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[299,298,297,300],"class_list":["post-1116","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-chronic-intestinal-disorder","tag-uc","tag-ulcerative-colitis","tag-ulcers"],"yoast_head":"\nDevelopment and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. Ulcerative colitis (UC) is a chronic intestinal disorder characterized by severe intestinal inflammation and superficial mucosal ulcers. Ramulus mori alkaloids (SZ-A) were approved by the National Medical Products Administration of China in 2020 for the treatment of type 2 diabetes mellitus. Later studies confirmed that SZ-A […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/\" \/>\n<meta property=\"og:site_name\" content=\"AMM Journal\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-21T08:07:31+00:00\" \/>\n<meta name=\"author\" content=\"Compuscript\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Compuscript\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/06\\\/21\\\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/06\\\/21\\\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\\\/\"},\"author\":{\"name\":\"Compuscript\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\"},\"headline\":\"Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres\",\"datePublished\":\"2024-06-21T08:07:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/06\\\/21\\\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\\\/\"},\"wordCount\":349,\"commentCount\":0,\"keywords\":[\"chronic intestinal disorder\",\"UC\",\"Ulcerative colitis\",\"ulcers\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/06\\\/21\\\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/06\\\/21\\\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\\\/\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/06\\\/21\\\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\\\/\",\"name\":\"Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres - AMM Journal\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\"},\"datePublished\":\"2024-06-21T08:07:31+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/06\\\/21\\\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/06\\\/21\\\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2024\\\/06\\\/21\\\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/amm-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/\",\"name\":\"AMM Journal\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/amm-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\",\"name\":\"Compuscript\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"caption\":\"Compuscript\"},\"sameAs\":[\"https:\\\/\\\/amm-journal.org\"],\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/author\\\/ammjadmin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres - AMM Journal","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/","og_locale":"en_GB","og_type":"article","og_title":"Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres - AMM Journal","og_description":"Announcing a new publication for Acta Materia Medica journal. Ulcerative colitis (UC) is a chronic intestinal disorder characterized by severe intestinal inflammation and superficial mucosal ulcers. Ramulus mori alkaloids (SZ-A) were approved by the National Medical Products Administration of China in 2020 for the treatment of type 2 diabetes mellitus. Later studies confirmed that SZ-A […]","og_url":"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/","og_site_name":"AMM Journal","article_published_time":"2024-06-21T08:07:31+00:00","author":"Compuscript","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Compuscript","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/#article","isPartOf":{"@id":"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/"},"author":{"name":"Compuscript","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67"},"headline":"Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres","datePublished":"2024-06-21T08:07:31+00:00","mainEntityOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/"},"wordCount":349,"commentCount":0,"keywords":["chronic intestinal disorder","UC","Ulcerative colitis","ulcers"],"articleSection":["News and Events"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/","url":"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/","name":"Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres - AMM Journal","isPartOf":{"@id":"https:\/\/amm-journal.org\/#website"},"datePublished":"2024-06-21T08:07:31+00:00","author":{"@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67"},"breadcrumb":{"@id":"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/amm-journal.org\/index.php\/2024\/06\/21\/development-and-characterization-of-temperature-sensitive-hydrogels-embedded-with-sodium-alginate-chitosan-microspheres\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/amm-journal.org\/"},{"@type":"ListItem","position":2,"name":"Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres"}]},{"@type":"WebSite","@id":"https:\/\/amm-journal.org\/#website","url":"https:\/\/amm-journal.org\/","name":"AMM Journal","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/amm-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67","name":"Compuscript","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","caption":"Compuscript"},"sameAs":["https:\/\/amm-journal.org"],"url":"https:\/\/amm-journal.org\/index.php\/author\/ammjadmin\/"}]}},"_links":{"self":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=1116"}],"version-history":[{"count":1,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1116\/revisions"}],"predecessor-version":[{"id":1117,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1116\/revisions\/1117"}],"wp:attachment":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=1116"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=1116"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=1116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}