{"id":1080,"date":"2024-05-07T08:25:57","date_gmt":"2024-05-07T08:25:57","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1080"},"modified":"2024-05-07T08:25:57","modified_gmt":"2024-05-07T08:25:57","slug":"nose-to-brain-drug-delivery-by-hs15-micelles-for-brain-targeting-of-insoluble-drug","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2024\/05\/07\/nose-to-brain-drug-delivery-by-hs15-micelles-for-brain-targeting-of-insoluble-drug\/","title":{"rendered":"Nose-to-brain drug delivery by HS15 micelles for brain targeting of insoluble drug"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. Agomelatine (AGO) is an antidepressant with limited clinical application due to its low bioavailability caused by poor water solubility, severe hepatic degradation, and poor intracerebral distribution. Nanotechnology-based strategies constitute a powerful tool by utilizing drug solubility and targeted distribution to improve drug bioavailability in the brain tissues by nose-to-brain drug delivery. In this study AGO was encapsulated within micelles using the commercially available Solutol HS15. As a result, AGO was efficiently loaded on the basis of least micelle size (14.17 \u00b1 0.72 nm) and encapsulation efficiency (96.96%).\u00a0In vivo<\/em>\u00a0and\u00a0ex vivo<\/em>\u00a0experiments showed that micelles provided higher and more sustained brain distribution. And the results of pharmacokinetic experiments showed that micelles entered the brain region rapidly after intranasal administration and reach its peak within 0.25 h. The behavior of the nanoparticles indicated that the micelles were observed across the olfactory epithelium by examination of nasal mucosal penetration. This demonstrates that HS15 micelles facilitate penetration of drugs in the olfactory epithelium and provide a system with which to target brain tissues and overcome the problem of inefficient drug delivery of insoluble drugs for central nervous system diseases.<\/p>\n

https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2023-0051<\/a><\/p>\n

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Wei Zhang, Long Wan and Meiqi Han et al. Nose-to-brain drug delivery by HS15 micelles for brain targeting of insoluble drug.\u00a0Acta Materia Medica.\u00a0<\/em>2024. Vol. 3(2):119-132. DOI: 10.15212\/AMM-2023-0051<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Agomelatine (AGO) is an antidepressant with limited clinical application due to its low bioavailability caused by poor water solubility, severe hepatic degradation, and poor intracerebral distribution. Nanotechnology-based strategies constitute a powerful tool by utilizing drug solubility and targeted distribution to improve drug bioavailability in the brain […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[274,271,272,273],"class_list":["post-1080","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-ago","tag-agomelatine","tag-antidepressant","tag-nose-to-brain-drug"],"yoast_head":"\nNose-to-brain drug delivery by HS15 micelles for brain targeting of insoluble drug - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2024\/05\/07\/nose-to-brain-drug-delivery-by-hs15-micelles-for-brain-targeting-of-insoluble-drug\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nose-to-brain drug delivery by HS15 micelles for brain targeting of insoluble drug - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. 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